ISSN : 1302-7123 | E-ISSN : 1308-5123

Hızlı Arama




The Clinicopathologic Differences Between Micropapillary and Papillary Thyroid Cancer [SETB]
SETB. Baskıdaki Makaleler: SETB-68790 | DOI: 10.14744/SEMB.2019.68790

The Clinicopathologic Differences Between Micropapillary and Papillary Thyroid Cancer

Kinyas Kartal1, Nurcihan Aygun2, Mehmet Uludag2
1Department of General Surgery, Koç University Hospital, Istanbul Turkey
2Department of General Surgery, Health Sciences University, Sisli Hamidiye Etfal Research and Practice Center, Istanbul Turkey

Objective: The aim of this study is observing the clinicopathologic features of the thyroid papillary microcarcinomas (PTMs) and comparing these features with papillary thyroid cancer (PTC).
Methods: 86 surgically treated patients with PTC were evaluated retrospectively. Group 1 (G1) included patients with a tumor less than 1 cm while group 2 (G2) included patients witha tumor larger than 1 cm. The two groups were compared in terms of preoperative thyroid- stimulating hormone (TSH) level, anti-thyroid peroxidase antibody (Anti- TPO) and antithyroglobulin antibody (TgAb) values, multicentricity, lymphovascular invasion rate, the presenceof extra-thyroidal extension, and central and/ or lateral lymph node metastasis.
Results: There was no statistically significant difference observed between the groups in terms of preoperative TSH level, anti- TPO, and Tg-Ab values. The rate of multicentricity of the tumor in G2 was 66% while it was 36% in G1 (p<0,001). The lymphovascular invasion rate in G1 was 14.2% while it was 61% in G2 (p< 0,001). Extrathyroidal extension rate of the tumor cells in G1 was 21.4% while it was 63.6% in G2 (p < 0,001). The central lymph node metastasis rate in G2 was 38.6% while it was 4.8% in G1 (p<0,001). The lateral lymph node metastasis rate in G2 was 20.5% while it was 0% in G1 (p<0,001).
Conclusion: PTMs are generally related with good prognostic factors with long survival rates. However, the risk factors such as multifocality, extrathyroidal extension, lymphovascular invasion increasing the recurrence risk are not rare in PTM. Thus, the patients having these histopathological features of the tumor should be followed more carefully.

Anahtar Kelimeler: Thyroid papillary cancer, thyroid micropapillary cancer, lymphovascular invasion, extrathyroidal extension, lymph node metastasis, prognosis.

The Clinicopathologic Differences Between Micropapillary and Papillary Thyroid Cancer

Kinyas Kartal1, Nurcihan Aygun2, Mehmet Uludag2
1Department of General Surgery, Koç University Hospital, Istanbul Turkey
2Department of General Surgery, Health Sciences University, Sisli Hamidiye Etfal Research and Practice Center, Istanbul Turkey

Objective: The aim of this study is observing the clinicopathologic features of the thyroid papillary microcarcinomas (PTMs) and comparing these features with papillary thyroid cancer (PTC).
Methods: 86 surgically treated patients with PTC were evaluated retrospectively. Group 1 (G1) included patients with a tumor less than 1 cm while group 2 (G2) included patients witha tumor larger than 1 cm. The two groups were compared in terms of preoperative thyroid- stimulating hormone (TSH) level, anti-thyroid peroxidase antibody (Anti- TPO) and antithyroglobulin antibody (TgAb) values, multicentricity, lymphovascular invasion rate, the presenceof extra-thyroidal extension, and central and/ or lateral lymph node metastasis.
Results: There was no statistically significant difference observed between the groups in terms of preoperative TSH level, anti- TPO, and Tg-Ab values. The rate of multicentricity of the tumor in G2 was 66% while it was 36% in G1 (p<0,001). The lymphovascular invasion rate in G1 was 14.2% while it was 61% in G2 (p< 0,001). Extrathyroidal extension rate of the tumor cells in G1 was 21.4% while it was 63.6% in G2 (p < 0,001). The central lymph node metastasis rate in G2 was 38.6% while it was 4.8% in G1 (p<0,001). The lateral lymph node metastasis rate in G2 was 20.5% while it was 0% in G1 (p<0,001).
Conclusion: PTMs are generally related with good prognostic factors with long survival rates. However, the risk factors such as multifocality, extrathyroidal extension, lymphovascular invasion increasing the recurrence risk are not rare in PTM. Thus, the patients having these histopathological features of the tumor should be followed more carefully.

Keywords: Thyroid papillary cancer, thyroid micropapillary cancer, lymphovascular invasion, extrathyroidal extension, lymph node metastasis, prognosis.



Sorumlu Yazar: Kinyas Kartal
LookUs & Online Makale