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Comparison of Oral Steroids, Macrolides and Combination Therapy in Nasal Polyposis Patients [SETB]
SETB. Ahead of Print: SETB-40316 | DOI: 10.14744/SEMB.2018.40316

Comparison of Oral Steroids, Macrolides and Combination Therapy in Nasal Polyposis Patients

Fatih Tetik1, Arzu Yasemin Korkut2, Kerem Sami Kaya2, Irmak Uçak3, İrfan Çelebi4, Berna Uslu Coşkun2
1Gaziosmanpaşa Taksim Eğitim Araştırma Hastanesi, Kulak Burun Boğaz Kliniği.
2Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği.
3İstanbul Sultan Abdülhamid Han Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği.
4Vehbi Koç Vakfı Amerikan Hastanesi, Radyoloji Kliniği.

Objective: Our aim was to compare oral steroid therapy with macrolide therapy and with oral steroid + macrolide (combine) therapy in nasal polyposis (NP) patients.
Material and Methods: All patients were treated with nasal steroid therapy for 8 weeks and divided randomly into 3 groups; Oral steroid group, oral macrolide group and combine group. All patients underwent endoscopic staging, radiological grading, odour testing and completed the sino-nasal outcome test-22(SNOT-22) questionnaire before and after treatment.
Results: Significant improvement was observed in all parameters after treatment in all 3 groups. All parameters were significantly better in the combined group than in the macrolide group. Comparison of the oral steroid group and macrolide group revealed significantly better radiological grading and odour test changes for the oral steroid group but no statistically significant differences existed according to endoscopic staging and SNOT-22. The post-treatment SNOT-22 score was significantly better in the combined group than in the steroid group. Comparison of the combined and steroid groups indicated better results for the combined group for all parameters, but the differences were not significant.
Conclusion: All treatment protocols were effective and the successful use of macrolide indicates its potential as an alternative in patients with contraindications to oral steroid treatment. The combined treatment may demonstrate significantly better results than steroid treatment alone if larger studies with more patients are performed.

Keywords: Chronic rhino sinusitis, Macrolide, Nasal polyposis, Nasal steroid, Oral steroid

Comparison of Oral Steroids, Macrolides and Combination Therapy in Nasal Polyposis Patients

Fatih Tetik1, Arzu Yasemin Korkut2, Kerem Sami Kaya2, Irmak Uçak3, İrfan Çelebi4, Berna Uslu Coşkun2
1Gaziosmanpaşa Taksim Eğitim Araştırma Hastanesi, Kulak Burun Boğaz Kliniği.
2Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği.
3İstanbul Sultan Abdülhamid Han Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği.
4Vehbi Koç Vakfı Amerikan Hastanesi, Radyoloji Kliniği.

Objective: Our aim was to compare oral steroid therapy with macrolide therapy and with oral steroid + macrolide (combine) therapy in nasal polyposis (NP) patients.
Material and Methods: All patients were treated with nasal steroid therapy for 8 weeks and divided randomly into 3 groups; Oral steroid group, oral macrolide group and combine group. All patients underwent endoscopic staging, radiological grading, odour testing and completed the sino-nasal outcome test-22(SNOT-22) questionnaire before and after treatment.
Results: Significant improvement was observed in all parameters after treatment in all 3 groups. All parameters were significantly better in the combined group than in the macrolide group. Comparison of the oral steroid group and macrolide group revealed significantly better radiological grading and odour test changes for the oral steroid group but no statistically significant differences existed according to endoscopic staging and SNOT-22. The post-treatment SNOT-22 score was significantly better in the combined group than in the steroid group. Comparison of the combined and steroid groups indicated better results for the combined group for all parameters, but the differences were not significant.
Conclusion: All treatment protocols were effective and the successful use of macrolide indicates its potential as an alternative in patients with contraindications to oral steroid treatment. The combined treatment may demonstrate significantly better results than steroid treatment alone if larger studies with more patients are performed.

Anahtar Kelimeler: Chronic rhino sinusitis, Macrolide, Nasal polyposis, Nasal steroid, Oral steroid



Corresponding Author: Fatih Tetik, Türkiye
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