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5 - Comparison of choroidal thickness in primary open angle glaucoma patients in the late phase after trabeculectomy and without trabeculectomy: enhanced depth imaging optical coherence tomography study
Muhsin Eraslan, Eren Çerman, Sezer Hacıağaoğlu
Objective: The aim of this study is to compare choroidal thickness using enhanced depth imaging optical coherence tomography between primary open angle glaucoma patients with or without previous trabeculectomy.
Material and Method: Fourteen eyes of 12 patients with a history of previous trabeculectomy surgery (TRAB) at least 6 months ago and 20 eyes of 12 patients who has a diagnosis of primary open angle glaucoma (POAG) and did not experience trabeculectomy surgery were recruited to this cross-sectional non-randomised study. Patients with a history of uveitis, diabetic retinopathy, age related macular degeneration, refractive errors other than the determined limits, optic neuropathy or other retinal, choroidal or optic nerve diseases were excluded. Following the complete ophthalmologic examination, choroidal thickness was measured between the hyperreflective outer layer of retinal pigment epithelium and inner layer of sclera, at subfoveal region and 1.5 mm temporal and 1.5 nasal to the fovea, respectively, using RTVue-100 5.1 (EDI-OCT) device.
Results: The mean age of the patients in the TRAB group was 59.9±13.4 (range 29-76), while it was 58.4±9.7 (range 29-73) in POAG group. Groups showed homogeneous distribution in terms of age, gender, laterality, IOP, refractive errors, visual acuity, axial length and central corneal thickness (CCT) (p>0.05). The mean subfoveal, temporal and nasal choroidal thickness of TRAB group was higher (388.2±84.1, 372.4±77.1, 374.1±84.1 µm, respectively) compared to the POAG group (383±64, 358.6±62, 357.5±61.5 µm, respectively), but the difference was not statistically significant (p>0.05). There was a moderate negative correlation between IOP and subfoveal and nasal choroidal thickness in patients with POAG (p=0.048, r=-0.458; p=0.042, r=-0.458; respectively)
Conclusion: There was not any statistically significant difference regarding subfoveal and perifoveal choroidal thickness between patients with previous trabeculectomy at least 6 months ago and patients with diagnosis of POAG who had medically regulated IOP rates and did not experienced trabeculectomy. Patients with POAG may experience choroidal thinning in case of high IOP rates.
Keywords: EDI optic coherence tomography, Choroidal thickness, primary open angle glaucoma, trabeculectomy
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