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4 - Cardiac troponin I levels in patients with severe preeclampsia and effect of magnesium sulfate treatment on cardiac troponin I levels
Ozgur Cot, Serkan Kumbasar, Aytek Şık, Mesut Demir, Erman Sever, Elif Sezin Kayaalti
Objective: It was aimed to investigate minor myocardial injury in preeclampsia by comparing troponin I levels in pregnant women with preeclampsia and normal pregnant women, and to examine the effect of magnesium sulfate treatment on cardiac troponin I levels.
Material and Method: The study included two groups as one preeclemptic group consisting of 25 pregnant women with preeclampsia (group 1) and a control group consisting of 25 pregnant women who do not have any medical or obstetric problem. Mean serum cardiac troponin I levels measured before and after magnesium sulfate treatment in pregnant women with preeclampsia were compared to troponin I levels in healthy pregnant women.
Results: There was no statistically significant difference between the two groups regarding their demographical properties (p>0.05). As for the comparison of mean cardiac troponin I levels between groups, there was marked and statistically significant difference between Group I (0.0944±0.044 ng/mL) and Group II (0.006±0.002 ng/mL) (p<0.05). In patients with preeclampsia (Group I), troponin I levels were higher before magnesium sulfate treatment (0.094±0.044 ng/mL) compared to levels measured after treatment (0.0048±0.0017 ng/mL), and the difference was statistically significant (p<0.05).
Conclusion: In our study, levels of troponin I, which is the best known indicator of minor myocardial injury, was higher in pregnant women with severe preeclampsia compared to the control group, suggesting myocardial injury related to hypertensive diseases in pregnancy. In addition, it was determined that magnesium sulfate treatment reduced troponin I levels and did not cause myocardial injury.
Keywords: Magnesium sulfate treatment, preeclampsia, troponin I
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