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          VOLUME 41 / ISSUE 4


The Journal is Indexed in


6 - Comparison of the effects of oral omeprazole, famotidine and ranitidine on gastric volume and ph in elective surgery patients

Hale Dobrucalı, Leyla T. Kılınç, G. Ulufer Sivrikaya, Melahat K. Erol, Ayşe Hancı, Metin Bektaş

Objective: In our study we aimed to compare the effects of H2 reseptor blockers {famotidin and ranitidine) and H-K ATPase inhibitor (omeprazole) on intragastric volume and pH in patients undergoing elective surgery under general anesthesia.

Study design: After the approval by the Medical Ethics Committee of our hospital, 80 patients in ASA I-II physical status randomized into four groups .The patients were given 20 mg omeprazole (group I) or 150 mg ranitidine (group 2) or 40 mg famotidine (group 3) by orally with 10 ml water 2 hours before anaesthesia induction. The patients in control group (group 4) were given 10 ml water alone. pH electrode was in¬serted transnasally and than gastric volume and pH measured at peroperative and 30 minutes postoperative période.

Results: Gastric volume was significantly higher in group 4 than other three groups at anaesthesia induction and extubation (p<0.001). Gastric volume values were significantly lower in Group 2 than group 1 and 3 (p<0.001). Number of high aspiration risk patiepts were significantly lower at group 1, 2, 3 than group 4 (p<0.05). Gastric volume pH values were lower at group 4 than the other groups peroperatively and recovery period (p<0.001 ).

Conclusion: This study showed omeprazole, famotidine and ranitidine can be used in to prevent gastric acit aspiration during general anesthesia safely.

Keywords: Gastric volume, gastric pH, aspiration pneumonia

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