The publication of University of Health Sciences, Istanbul Sisli Hamidiye Etfal Medical Practice and Research Center

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          VOLUME 41 / ISSUE 2

The Journal is Indexed in

3 - The effect of topical latanoprost on retrobulbar blood flow in patients with primary open angle glaucoma and ocular hypertension

Ersin Oba, Ulviye Yiğit, Fatma Koca, Burcu Dirim, Alper Özel, Muzaffer Başak

Purpose: To investigate the effects of topical latanoprost 0,005% on retrobulbar vessel blood velocity in patients with primary open-angle glaucoma (POAG), norrnotansive glaucoma (NTG) or ocular hypertension (OH).

Material and Method: Twenty patients with POAG, NTG or OH were enrolled for this study All patients were treated topically with latanoprost 0. 005 % (Xalatan). Follow-up time was three months. Each patient had a baseline color Doppler Imaging ultrasound of the central retinal artery, posterior ciliary artery, ophtalmic artery and second color doppler ultrasound examination three months later. Intraocular pressure (IOP) in each patient was also recorded with Goldman applanation tonometer before the treatment and at the end of three months follow-up.

Results: Twenty patients completed the study. Topical latanoprost significiantly reduced intraocular pressure (p<0.05) The only significant change observed in the retrobulbar blood velocity with latanoprost treatment was an increase of end diastolic velocity in the posterior ciliary artery (p<0.05). No change in the other blood velocity measurements was observed with latanoprost treatment.

Conclusion: Topical latanoprost significantly reduced the intraocular pressure in ocular hypertensive and glaucoma patients and didn’t make unexpected changes on retrobulbar blood flow; also made an increase of end diastolic velocity in the posterior ciliary artery.

Keywords: Latanoprost, Retrobulbar blood flow, primary open angle glaucoma, Ocular hypertension, Norrnotansive glaucoma, Color Doppler imaging

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