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2 - Diagnostic value of serum ferritin, c-reactive protein, Iron and total iron binding capacity in metastatic and non metastatic breast cancer patients
Berna Aslan, Fatma Turgay, Şebnem Ciğerli, Nihal Yücel Nezaket Eren, Emel Yorgancı
Objective: In this current study, we investigated the iron (FE), total iron binding capacity (TIBC), ferritin, and C-reactive protein (CRP) levels in breast cancer patients with and without metastasis.
Study Design: To this aim, 40 breast cancer women, 20 with metastasis, 20 without metastasis, and a control group of 20 healthy women were included in the study. Ferritin, iron, and TIBC were measured in Hitachi 717 autoanalyser, and CRP levels were detected by nephelometric method.
Results: The mean serum ferritin level was 60.60 ng/ml in control group (group 1), 59.55 ng/ml in non-metastatic patient group (group 2), and there was not any significant difference between this two groups (p>0.90). Contrarily, the mean ferritin level was 427.25 ng/ml in metastatic patient group (group 3), and this was significantly different from the means of group 1 and 2 (p<0.001, p<0.001). Serum iron levels means were respectively 65.75 pg/dl, 83.40 pgldL, 66, 0 pg/dl in group 1, 2, and 3. There was not any difference between group 3 versus group land 2 (p>0, 9, p>0,1). The mean serum TIBC level was 302.15 pg/dl in group 1 and 366.20 pg/dl in group 2, and there was a significant difference between two groups (p< 0.001). On the other hand, the mean TIBC level of group 3 was 312.75 pg/dl, and this was significantly different from group 2 (p<0.020) but did not show any difference from group 1 (p:0.3-0.5). The mean serum CRP level was 0.75 mg/l in group 1, 2.20 mg/l in group 2, and there was not any significant difference between two groups (p>0.3). This value was 42.25 mg/l in group 3, and it was significantly different from group 1 and 2 (p<0.001).
Conclusions: We found that serum CRP, TIBC, and ferritin values were significantly different in metastatic breast cancer patients than those of non-metastatic breast cancer patients and those of healthy control indivuduals.
Keywords: Iron, total iron binding capacity , ferritin, and Creactive protein.
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