The publication of University of Health Sciences Istanbul Sisli Hamidiye Etfal Application and Research Center.


Online article submission system has been turned over to eJManager. We kindly request you to submit your current article or new articles via eJManager system

          VOLUME 40 / ISSUE 4


The Journal is Indexed in


2 - Diagnostic value of serum ferritin, c-reactive protein, Iron and total iron binding capacity in metastatic and non metastatic breast cancer patients

Berna Aslan, Fatma Turgay, Şebnem Ciğerli, Nihal Yücel Nezaket Eren, Emel Yorgancı

Objective: In this current study, we investigated the iron (FE), total iron binding capacity (TIBC), ferritin, and C-reactive protein (CRP) levels in breast cancer patients with and without metastasis.

Study Design: To this aim, 40 breast cancer women, 20 with metastasis, 20 without metastasis, and a control group of 20 healthy women were included in the study. Ferritin, iron, and TIBC were measured in Hitachi 717 autoanalyser, and CRP levels were detected by nephelometric method.

Results: The mean serum ferritin level was 60.60 ng/ml in control group (group 1), 59.55 ng/ml in non-metastatic patient group (group 2), and there was not any significant difference between this two groups (p>0.90). Contrarily, the mean ferritin level was 427.25 ng/ml in metastatic patient group (group 3), and this was significantly different from the means of group 1 and 2 (p<0.001, p<0.001). Serum iron levels’ means were respectively 65.75 pg/dl, 83.40 pgldL, 66, 0 pg/dl in group 1, 2, and 3. There was not any difference between group 3 versus group land 2 (p>0, 9, p>0,1). The mean serum TIBC level was 302.15 pg/dl in group 1 and 366.20 pg/dl in group 2, and there was a significant difference between two groups (p< 0.001). On the other hand, the mean TIBC level of group 3 was 312.75 pg/dl, and this was significantly different from group 2 (p<0.020) but did not show any difference from group 1 (p:0.3-0.5). The mean serum CRP level was 0.75 mg/l in group 1, 2.20 mg/l in group 2, and there was not any significant difference between two groups (p>0.3). This value was 42.25 mg/l in group 3, and it was significantly different from group 1 and 2 (p<0.001).

Conclusions: We found that serum CRP, TIBC, and ferritin values were significantly different in metastatic breast cancer patients than those of non-metastatic breast cancer patients and those of healthy control indivuduals.

Keywords: Iron, total iron binding capacity , ferritin, and Creactive protein.

To read full article click


Home Page       Editorial       Editorial Board       Advisory Board       Information for Authors       Contact       Archive

Copyright ® 2011 Sisli Etfal Hastanesi Tıp Bülteni