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          VOLUME 40 / ISSUE 2


The Journal is Indexed in


4 - Comparison of propofol and midazolam combined with remifentanil for anaesthesia in middle ear surgery

G.Ulufer Sivrikaya, Hasan Çoruk, Ebru H. Koç, Ayşe Hancı

Objective: The aim of this study was to compare the effects of propofol and midazolam combined with remifentanil on peroperative bleeding, haemodynamy and postoperative recovery characteristics when used for anaesthesia in middle ear surgery.

Study design: Thirty patients undergoing tympanoplasty were included the study and randomly assigned two groups after infusion of 8 mil kg cry staloid solution. Anaesthesia was induced with remifentanil and propofol in Group I or midazolam in Group II. In the maintenance of anaesthesia combination of 02/N20, remifentanil continuous infusion and propofol continuous infusion in Group / or midazolam continuous infusion in Group II were used. Systolic, diastolic, mean arterial pressure (SAP, DAP, MAP), heart rate (HR) values were recorded before induction and at 10 min intervals per operatively. Drug dosages were adjusted to maintain the peroperative MAP below %25 of basal MAP. Glyserol trinitrat was used when marked MAP was unachieved. Bleeding in the surgical field, recovery characteristics and adverse effects were recorded. Results were analysed with analyses of variance, student‘s t and chi sguare tests, p<0.05 was considered as signifi¬cant.

Results: The time to achieve marked MAP value was significantly shorter in Group / than Group 11 (p<0.05). Glyserol trinitrat was used in 10 patients in Group II to achieve marked MAP (p<0.05). MAP was higher before extubation and HR was lower after extuhation in Group I than Group II (p<0.05). Bleeding in the surgical field, recovery characteristics and adverse effects were similar between the groups.

Conclusion: In conclusion; combination of propofol with remifentanil provided better results than midazolam when used for anaesthesia in middle ear surgery.

Keywords: Remifentanil, propofol, midazolam, middle ear surgery.

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