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9 - Determination of osteocalcin levels as a bone marker in controlled and uncontrolled niddm
Nezaket Eren, Şebnem Ciğerli, Nihal Yücel, Fatma Turgay Berna Aslan, Bilgehan Akman
Serum and/or urine consantrations of a number of markers allow us to evaluate indirectly bone metabolism. Recently, serum osteocalcin (OC) used in the assessment of bone formation, is becoming more important in diabetic osteoporosis researches as a valuable marker of bone turnover. In our study, we compared serum OC levels in patients of uncomplicated NIDDM, aging 45 and 30, and control group. We divided our patient group into 2 subgroups: controlled (7 male and 13 female) and uncontrolled (10 male and 10 female). Our control group consisted of 30 indivuduals, 12 males and 13 females. There were no significant differences between controlled (!) and uncontrolled (2) groups with respect to serum ALP, phosphorus (P), calcium (Ca), magnesium (Mg) and OC (p>0.05) values. A significant difference was found between controlled (1) and uncontrolled (2) patient groups and control groups calcium and OC levels (p<0.005 and p<0.05, p<0.05 and p<0.001 respectively). While there was not any correlation between serum OC and serum ALP, P and Ca values (r values respectively: r=0.38, r=0.21, r=0.27), a positive correlation was observed between OC and Mg values (r=0.53).
In previous studies in Type II Diabetes Mellitus, OC levels in patient groups were found lower than those of control groups. This suggests that in evaluating bone metabolism, serum OC values are more useful than the other invasive methods used in the diagnosis of osteoporosis
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