2 - Autologous serum skin test of patients with chronic urticaria
Fulya Göksu, Gonca Gökdemir, Adem Köşlü
Objective: Chronic urticaria (CU) is a common skin disorder Previous studies defining the clinical features of patients with chronic idiopathic urticaria (CIU) were performed before the identification of functional autoantibodies against Fc_Rl.Some recent studies showed that approximately one- third of patients with CIU had circulating functional autoantibodies against the high affinity IgE receptor FcJRI and/or IgE.
We aimed to use Autologous Serum Skin Test (ASST) in the patients with CU.
Study design: Between October 2000-April 2001, ASST were performed in 30 CU patients and 10 healty controls. We used
0. 1 ml autologous serum and 0.9% phosphate buffered saline solution on both forearms.
Results: ASST were positive 24 (80%) out of 30 patients with CU and ASST were positive,4 out of 10 healty controls. The difference was significant as statisticall.
Conclusion: Chronic urticaria remains a major problem in terms of etiology, investigation and management. As a result of this study we can use ASST in patients who had chronic urticaria as pretest.
Keywords: Autologous Serum Skin Test (ASST), Chronic Urticaria (CU).
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