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2 - Prognostic factors in cervix cancer
Didem Karaçetin, Özlem Maral, Begüm Ökten Öznur Aksakal, Oktay Ýncekara
Purpose: Our aim was to study, in Cervix cancer patients, retrorespectively, the prognostic factors in relation with the ratio between survival and local-recurrence.
Material & Method: Some 108 pateients were chosen, from among 166 who were treated at Si§li Etfal Hospital between 1992- 2002 and had been followed-up at our clinic for 6 or more months.Median Age: 52 (22-88).Histological Diagnosis: 96 patients were squamous cell ca, 20 patients were adenocarcinoma and 2 patients were small cell Ca.
Stages: 13 patients were stage IB, 14 were stage HA, 25 were IIB, 6 were IIIA, 31 were IIIB, 12 were IVA-IVB. All patients were received radiotherapy with Co60. Stage IB and HA patients were received radiotherapy as adjuvant after radical hysterectomy. Stage IIB-IV patients were received radiotherapy alone or concomitant with chemotherapy.External radiotherapy was given to 50 Gy (1.8-2 Gy/fr), parametria! boost 10 Gy was given to patients with parametriaI invasion (n=37).ICRT (Intracav.it.er. radiotherapy) 20-25 Gy was given after external radiotherapy.
Results: General Survival Rate in relation with stages are: 47.3 months for stage IB, 31.5 months for stage 11 A. 26.5 months for stage IIB, 23.9 months for stage HI A, 22.3 months for stage IIIB, 19 months for stage IVA and 9 months for stage IVB.
39 patients had recurrence at their follow-ups. 41 % of the recurences happened with patients (+) lymph node. All of 9 patients with pataaortic lymph node métastasés at diagnosis had recurrence. 6 patients had bone, 4 patients had liver, 3 patients had lung and / patients had colon métastasés during follow-up.
Discussion: Pelvic lymph node métastasés at diagnosis is the major prognostic factor (p=().()l). Patients with paraaortic lymph node métastasés prognosis is worse. Age and hystopcithologic type are less important in prognosis. Radiotherapy with concomitant chemotherapy have positive effect on prognosis with high risk patients (p=0.05).
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