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          VOLUME 39 / ISSUE 1


The Journal is Indexed in


6 - The effects of different doses of remifentanil on sedation, haemodymamy and respiratory parameters in spinal anaesthesia

B. Çağla Özbakış Akkurt , G. Ulufer Sivrikaya, Leyla T. Kılınç, Melahat K. Erol, Ayşe Hancı, Ebru H. Koç

Objective: In our study, we aimed to assess the effects of different doses of remifentanil on sedation, haemodynamic and respiration parameters in spinal anaesthesia.

Study design: After the approval by the Medical Ethics Committee 46 patiens in ASA 1-11, undergoing urological operation were enrolled the study. AH patients received 1000 cc lactated ringer solution 1 hour before operation and premedicated with 0.02 mg.kg-1 midazolam. After standard spinal anaesthesia surgery was allowed when sensorial block was reached to thlO. All patients received 0.5 microg.kg-1 remifentanil at the beginning of the operation and randomised into three groups. Remifentanil was infused in a rate of 0.015 microg.kg-1 .min-1 in Group 1 or 0.03 microg.kg-1 .min-1 in Group II or 0.05 microg.kg-1 .min-1 in Gro¬up 111. Systolic, diastolic arterial pressures, heart rate, respiration rate, sensorial block level, sedation score were recorded every 5 minutes. Side effects were observed and recovery was evaluated.

Results: Systolic and diastolic arterial pressure values were lower in Group III than Group I and II. The difference was significant at 15.min. Sedation score values were significantly higher in Group III than Group I and II at 20.-45. min. Other study parameters were comparable between the groups.

Conclusion: Remifentanil provided a smooth haemodynamic profile and an adequate sedation level during spinal anaesthesia, thus appears to be an appropriate sedative agent in our study. Remifentanil induced respiratory depression requires cautious administration of this agent when used in higher doses.

Keywords: Remifentanil, spinal anaesthesia, sedation.

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