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2 - Haemostatic parameters in hypertensive patients and relationship with target organ damage
N. Deniz Esin, Aslan Çelebi, Vildan Ercan, Deniz Koç, Elmas Biberci, İsmail Ekizoğlu, Yüksel Altuntaş
Objectives: We investigated the relationship between target organ damage (TOD) and haemostatic parameters in hypertensive patients.
Methods and Materials: Fifty-five hypertensive patients and 25 healthy subjects. Were enrolled in this study after 8-10 hours of fasting haemostatic parameters; fibrinogen, fibrin D-dimer, protrombin time (PT), partial thromboplastin time (PIT), platelets, and lipid parameters (total cholesterol, HDL-cholesterol, LDL- cholesterol, triglycerides) have been studied in blood sample. To determine target organ damage, hypertensive nephropathy, hypertensive retinopathy and left ventricle hypertrophy were evaluated.
Results: In hypertensive group HDL-cholesterol levels were lower (p<0.001) and LDL-cholesterol (p<0.001) and triglyceride levels (p<0.001) were higher than healty subjects.
In hypertensive group, the levels of serum fibrinogen and D-dimer were higher (p <0.001) than that of healty subjects. No signi¬ficant differences have been found in terms of platelets and PT when hypertensive patients and control groups were compared. It has been found that there is significant relationship between ha¬emostatic parameters and TOD in hypertensive patients (p<0.05). Serum fibrinogen and D-dimer levels were higher (p<0.()01) in hypertensive patients with TOD.
Conclusions: As fibrinogen and D-dimer levels were found hig¬her in hypertensive patients than healty subjects, it is considered that hypertension is related with haemostatic disorders. High le¬vels of fibrinogen and D-dimer are related with TOD.
Keywords: hypertension, target organ damage, haemostasis
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