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2 - The effects of antihypertensive agents on endometrial thickness in asymptomatic postmenopausal women
Nuran Yılmaz, Hüseyin Özkurt, Hülya Değirmenci A. Deniz Kahraman, Muzaffer Başak
Objective: The aim of our study was to retrospectively investigate, by using transvaginal ultrasonography, the possible effects on endometrial thickness of hypertension and antihypertensive agents in asymptomatic postmenopausal women.
Material and methods: We reviewed clinical and sonographic data on 217 un"ed, asymptomatic postmenopausal women who attented our department for routine abdominopelvic sonographic evaluation during two year period. 77 patients were included in the study (age range, 47-69 years). Reasons for exclusion were: clinical data about hypertension were not available (n=84), the patient had received or was receiving hormonal treatment (39), the patient had undergone a hysterectomy (n=17). We compared three groups of postmenopausal women (n-77) as follows: group (1) normotensive postmenopausal women, group (2) hypertensive women treated with an antihypertensive drug at least for a year, and group (3) untreated hypertensive women who had had hypertension for at least 1 year. All patient had been examined using transvaginal sonography. Endometrial thickness was measured at the level of its maximum thickness in the uterine sagittal plane.
Results: 57 women (% 74) were hypertensive and 20 women (% 26) were normotensive.Of the fifty-seven women, 39 (% 68) were receiving an antihypertensive drug at least 1 year. 18 women were untreated hypertensive patients for a year. The mean (± SD) endometrial thickness in groups 1, 2, 3 were 3.6 (± 0.2), 6.2 (± 1.1), 4.3 (± 1.2) mm, respectively. Significant difference was obtained in group 2 (p<0.05).
Conclusions: Our data indicate that the mean endometrial thickness is significantly greater in asymptomatic, hypertensive women receiving antihypertensive drugs than among untreated hypertensive and normotensive women.
Keywords: Endometrial thickness, hypertension
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