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          VOLUME 38 / ISSUE 2


The Journal is Indexed in


7 - Comparison of the effects of propofol and sevoflurane on liver-renal function tests and recovery characteristics in long lasting surgeries

G. Ulufer Sivrikaya, Ayşe Hancı, Banu Burgutoğlu, Fatma Gündoğan, Şükrü Çiftçi

Objective: The aim of this study was to compare the effects of propofol and sevoflurane anaesthesia on renal and hepatic function tests and recovery characteristics in long lasting surgeries.

Study design: After the approval by the Medical Ethic Committee of the hospital, 36 patients in ASA l-II physical status were randomized two groups. Anaesthesia was induced with propofol and atracuriurn and maintained with propofol infusi¬on (4-8 mg/kg/h) in Group P and with sevoflurane (2-3%) in Group S. Blood urea nitrogen, serum creatinin, AST, ALT levels were determined preoperatively, every 2 hours peroperatively, 30. min and 24 th hours postoperatively. As recovery characteristics time until eye opening, response to verba! commands, orientation-cooperation time were evaluated.

Results: Anaesthesia time was 349.7 minutes in Group P and 355.5 minutes in Group S. Laboratory values were similar between groups. There was not any significant difference between preoperative and postoperative values. Time until eye opening and response to verbal commands were shorter in Group P than Group S, but the difference was not significant. Orientation-cooperation time was statistically longer in Group S than Group P.

Conclusion: Propofol or sevoflurane has not any significant effect on liver or renal function tests, but recovery was faster with propofol in patients undergoing long lasting surgeries.

Keywords: Sevoflurane, propofol, liver-renal function, recovery

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