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          VOLUME 38 / ISSUE 1

The Journal is Indexed in

6 - Additional rosiglitazone therapy to other oral antidiabetic combinations or insulin therapy provides metabolic control in patients with type 2 diabetes

Sema Uçak, Okcan Basat, Selçuk Şeber, Akın Kürklü, Çiğdem Yazıcı Ersoy, Yüksel Altuntaş

Objective: This study tries to evaluate the efficacy of use of rosiglitazone in combination with other oral antidiabetic agents (at least two) or insulin treatment.

Study Design: This was a single centre, randomized, controlled, open, prospective trial. A total number of 90 type 2 diabetic patients, 37-82 years old were eligible for the study if they had HbAlc values over 7%, C-Peptide level greater than 0. 6 nmol/L, BMl between 20-40 at screening. Exclusion criteria were patients with angina or cardiac insufficiency, renal impairment, hepatic disease. Patients has already been treated with OADs (group 1, n=40) or insulin (group2, n=50) twice daily and had similar age and BMl, and a poor metabolic control (HbAl c>7%) under at least 3 months of therapy. A rosiglitazone maleate 4mg/day therapy was added to their previous therapies. All patients were followed up for 24 weeks.

Results: In group 1, additional rosiglitazone therapy reduced HbAlc from baseline by 1.63 percentage points (p=0.000) af¬ter 24weeks. In group 2, additional rosiglitazone therapy reduced HbAlc from baseline by 0.83 percentage points (p=0.000) after 24weeks.

Conclusion: Our study showed that rosiglitazone treatment is both effective in combination OAD or insulin treated patients with type 2 diabetes who have poor metabolic control.

Keywords: Rosiglitazone, type 2 diabetes mellitus.

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