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          VOLUME 38 / ISSUE 1

The Journal is Indexed in

5 - Comparison of effects of additional carvedilol and metoprolol therapy in patients with myocardial infarction on insulin resistance and serum lipid profile

Okcan Basat, Sema Uçak, Erkan Öztekin, Selçuk Şeber, Akm Kürklü, Dilek Argon, Yüksel Altuntaş

Objective: Cardioprotective effects and diminishing the in¬farct size in myocardium is well known features of beta bloc¬king agents. Previous studies showed that cardevilol has the same effects. The aim of our study was to compare the effects of carvedilol; an alpha-] and non "ive beta blocking agent and metoprolol, a "ive beta blocking agent, on insulin resistance and serum lipid levels in patients after myocardial infarction.

Study Design: Forty patients aged between 30 to 70 and BMI=25-30 kg!m2; who attended to our coronary intensive care unit within 24 hours of their angina and diagnosed as myocardial infarction with ST segment elevation are included in our study. Metoprolol 50mg/day (group I, n=20) or carvedilol 6.25mglday (group 2, n=20) was added to their combined therapy of acetylsalicilic acid, ramipril, isosorbide mononitrate and atorvastatin. Patients were followed up for 12 weeks. Baseline to week 4 and week 12 in fasting blood glucose, serum lipid profile, BMI, C-peptide, insulin and HO¬MA-IR levels were measured.

Results: In group 1, after 12 weeks of metoprolol therapy HOMA-IR, insulin and C-peptide levels were significantly higher than baseline (p=0.002, p=0.008 ve p=0.000, respectively) and week 4 (p=0.00I, p=0.64 ve p=0.014, respectively). In group 2, after 12 weeks of carvedilol therapy we observed the significant reduction of HOMA-IR, insulin and C- peptide (p=0.002, p=0.000, p=0.008, respectively).

Conclusion: The data of this study showed that in patients after myocardial infarction, an added carvedilol therapy provided an improvement in insulin resistance.

Keywords: Carvedilol, metoprolol, insulin resistance, myocardial infarction.

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