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9 - Correlation between the bone mineral density and the circulating bone metabolism markers in niddm male patients
Aysun Toker, Şebnem Ciğerli, Nezaket Eren, Fatma Turgay, Banu Kuran
Objective: In this study we aimed to find the effect or effects of diabetes in the bone metabolism.
Study Design: We chose the bone formation markers like ALP, OC and biochemical parameters that are closely releated to bone metabolism like Ca, P, Mg, PTH, vit D. We measured the insulin and C peptid levels in all patients in the study group and also BMD is performed for all patients and bone measurement values are defined as BMC (grlcm2), T score and Zscore. Our study group was performed by male patients aged between 42-83. Diabetic female patients were not included in our study because of the possible differentiations that could be caused by sex differences. We divided the NIDDM male patients into 2 groups according to their 24 hours urine protein levels. Our control group is performed by the same aged volunteers. According to this, we had a 36 normoalbuminuric diabetic male group, a 24 microalbuminuria male group and 20 healty male control group.
Results: We did not find any difference in OC, BMC, T score and Zscore between normoalhuminuric and miicroalbuminuric diabetic patients groups (Table 2). OC levels were found to be higher in diabetic patient groups when compared with controle group. This is statistically in contradiction to literature. We did not find any difference in BMC and Tscore levels between the groups. Only in Z score levels, we found statistically meaningful results between microalbuminuria group and control group (p<0,05). We did not give importance to this because our countries normals are not used in Z score measuring. When all the groups are studied together, we found that OC levels were not effected from glucose, Hb Alc, Ca, Mg, P, vit D, PTH, insulin and BMD parameters in our study.
Conclusions: In our study; we did not find any difference in bone densitometry parameters between diabetic and control groups. That means, we can speculate that osteoporosis or osteopenia are not complications type 2 DM. We found the OC levels to be higher in diabetic group in contribution to literature. More extensive studies are needed to show the bone metabolism in diabetic patients. We think that, performing studies with growth factors like IGF-l and interleucins will help us to better understand the patogenetic mecanisms.
Keywords: Osteocalsine, Bone Mineral Density, Bone Mineral Content, NIDDM
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