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8 - Plasminogen activator inhibitor-1 and fibrinogen levels in patients with acute myocard infarction
Akın Kürklü, Fatih Borlu, Levent N. Aydın, Sema Uçak, Ahmet M. Şengül, Çiğdem Y. Ersoy, Nezaket Eren, Yüksel Altuntaş
Aim: To investigate the levels of two haemostatic factors, fibrinogen and Plasminogen Activator Inhibitor (PAI-1) in patients with acute myocardial infarction (AMI).
Material and Methods: 30 patients with AMI (19 male, II female; age=62.7±I1.4) who were admitted at Sisli Etfal Education and Research Hospital, Coronary Care Unit in the first 24 hours from the beginning of symptoms were investigated. The results were evaluated according to gender, age, localization of Ml, presence of other diseases, cigarette and alcohol use. Statistical data analyses were done with Mann-Whitney U, K2, Kruskall-Wallis, Spearman correlation tests in SPSS program.
Results: The mean PAI-1 value of the patients was 2,6567±1725 U/ml and mean fibrinogen value was 489.0101163.052 mg/dl. There was a significant positive correlation between PAI-1 and fibrinogen levels (p=0.003). The highest fibrinogen levels were found in non-Q wave MI and the lowest values were found in inferior MI. There was a significant relation between fibrinogen levels and MI localizations (p=0.006). Mean fibrinogen levels were higher in females than males, and this difference was statistically significant (p=0.043). There was a significant correlation between fibrinogen and MI type, gender, and PAI-1 levels (p=0.031, p-0.041, p=0.003 respectively.
Conclusion: There was a statistically significant positive correlation between PAI-1 and fibrinogen levels in patients with AMI. Also there was a significant positive correlation between fibrinogen levels and MI type, gender, and PAI-1.
Keywords: AMI, PAI-1, fibrinogen.
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