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5 - Serum ECP and Total IgE levels in children with acute laryngotracheobronchitis
Mahmut Çakır, Feyzullah Çetinkaya, Nergis Yamak, Fadıl Öztürk
Objective: Acute laryngotracheobronchitis (ALTB) is a viral infection disease which appears generally in young children. In this study, eosinophil cationic protein (ECP) and immunoglobulin E (IgE) levels in the sera of patients with ALTB were measured and relationship between these markers and recurrent ALTB attacks were investigated.
Study design: Serum ECP and IgE levels were measured before treatment and in the third day and third week after treatment in 27 patients with ALTB whose ages ranged from ten months to five years, and were compared with a control group including 18 healthy children at the same age. All patients were given nebulized hudesonide treatment.
Results: Pretreatment ECP levels were significantly higher than posttreatment 3rd days and 3rd weeks (28.3 ± 2.3 ng/ml vs 20.2 ± 3.2 ng/ml and 11.4 ± 7.7 ng/ml respectively). Similarly, the mean pretreatment serum IgE values were significantly higher than post-treatment values (131.6 ± 17.5 lU/ml vs 83.6 ± 12.4 IU/ml and 68.2 ± 6.7 Ill/ml). A positive correlation was found between serum ECP and IgE values for pretreatmnet and posttreatment 3rd week values (r=062, p=().()l and r-0.64, p-O.OI, respectively). The pretreatment serum ECP and IgE levels were significantly higher than those of controls (10.8 1.5 ng/ml and 43.8 ± 6.6 IU/ml, respectively p0.05).
Conclusion: In this study it was shown that, serum ECP and IgE levels increase in the acute phase of infection and return to normal after treatment in patients with ALTB such as in allergic patients.
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