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4 - Comparison of three antibacterial regimens in the treatment of tonsillopharyngitis due to beta-hemolytic strepto cocci in children
Zeki Toplu, Günsel Kutluk, Feyzullah Çetinkaya, Metin Uysalol, Merih Akışık
Objective: Comparison of the efficacy of oral penicillin, clarithromycin and azithromycin in the treatment of patients with tonsillopharyngitis due to group Afihemolytic streptococcus (GABHS) in throat cultures.
Patients and methods: The study included 60 patients diagnosed with acute tonsillopharyngitis whose throat cultures revealed GABHS. These patients were divided randomly and equally into three groups. First group was treated with oral penicillin and the second group with clarithromycin for 10 days. The third group was treated with azithromycin for 3 days. The efficacy of treatment was evaluated by the presence or absence of growth in throat cultures done 3-7 days after the completion of the therapy.
Results: Bacterial eradication was achieved in 19 patients in the penicillin (95 %) and in all of the patients (100 %) in clarithromycin and azithoromycin groups. There were no statistically significant differences between the groups in regard to bacterial eradication rate. (P > 0.05).
Conclusion: It is concluded that azithromycin and clarithromycin can also be effectively used as well as conventional oral penicillin in the bacterial eradication and treatment of GABHS tonsillopharyngitis.
Keywords: tonsillopharyngitis, oral penicillin, azithromycin, clarithromycin, therapy
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