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10 - Effectiveness of preemptive epidural neostigmine in patient controlled epidural analgesia after abdominal hysterectomy
Fidan Aygün, G. Ulufer Sivrikaya, Ayşe Hancı, Melahat Karatmanlı Erol, Ayda Başgül
Objective: In our study we aimed to evaluate the postopi ve analgesic efficacy of preemptive epidural neostigmine
Study Design: After the approval by the Medical Ethic < mittee, 45 patients in ASA I-II aged between 40-65 years included into the study. 10 ml 0.9% NaCI solution in Grc
0. 5 mg neostigmine in Group II, 0.5 mg neostigmi.ne+2. bupivacaine in Group III were administered epidurally 21 nut.es before induction. Standard general anaesthesia applied to the patients. Mean arterial pressure (MAP), i rate (HR), peripheral oxygen saturation were recorded / peratively. Patient controlled epidural analgesia was use postoperative pain management. MAP, HR, pain evciliu with Visual Analogue Scale (VAS), adverse effects at post rative I., 2., 6., 12., 24. hours, total analgesic consumj for 24 hours were recorded. Students t test and ANOVA used for the statistical analyses. P<0.05 was considered nificant.
Results: MAP, HR values were not significantly differen. and postoperatively. VAS, total analgesic consumption frequency of adverse effects were lower in Group III v compared with other two groups.
Conclusion: Preemptive epidural neostigmine decrease toperative pain and analgesic consumption when comb with bupivacaine. We suggest that, neostigmine and I anaesthetic combination can be a good choice (for post rative analgesia) after abdominal hysterectomies.
Keywords: Patient controlled analgesia, preemptive, neo mine.
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