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5 - Before and after dialysis antithrombin III levels in patients on continuous hemodialysis
Fatma Turgay, Şebnem Ciğerli, Bahar Türkmen, Nezaket Eren
Objective: Both bleeding tendency and thrombotic complica¬tions are seen together in advance renal failure. Because oj the blood contacts on artificial surface during hemodialysis the activation of platelets and clotting factors lead to clot for¬mation in the extracorporeal circuit and this still remains as a potential problem. Patients undergoing regular hemodialysis are subject to height risk of thrombotic complications. The low levels of antithrombin III play a role with the genesis oj these complications. AT III is a major inhibitor of blood co¬agulation and hereditary deficiency is associated with venous thrombotic disease. We measured plasma AT III, fibrinojen, active partial thromhoplastine time (aPTT) and protrombin time (PTT) in order to investigate the activation of coagulati¬on before and after dialysis in patients with chronic renal fa¬ilure undergoing regular hemodialysis.
Study Design: Patient group was 50 people and control gro¬up was 20 people. We determined AT III via cromogenic substrat method, by using Hitachi-717 otoanalyzer produced by Boehringer Mannheim.
Results: We found the mean value for AT III activity 103,8%±8,85 in healthy controls. The mean values for AT III before dialysis and after dialysis were respectively 84,56%±I3,0 and 99%±J4,12 in patients with chronic renal failure.
Conclusions: As compared with the healthy controls, the pa¬tients with chronic renal failure had significantly lower (p:0.000) AT III activity before dialysis and significantly inc¬reased AT III activity after dialysis, (p: 0.000)
Keywords: AT III, Hemodialysis, Chronic Renal Failure
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