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9 - Effects of high dose vitamin A supplementation on the treatment of lower respiratory tract infections in infants
Cengiz Asilsoy, Feyzullah Çetinkaya, Merih Evrüke, Metin Uysalol, Günsel Kutluk
Objective: In this study the affect of a high dose of vitamin A as adjuvant treatment for cases with acute lower respiratory tract infection was tested in infants.
Study design: We conducted a randomized, double-blind, placebo- controlled clinical trial of high-dose vitamin A supplements among children aged 2 to 24 months (N - 40) admitted to hospital with bronchopneumonia or bronchiolitis. Vitamin A (100,000 IU for children less than 1 year of age, and 200,000 IU for older children) or placebo were given to the children in addition to standard treatment regimens . The children were assessed with clinical findings four times a day and with laboratory tests at the begining and fifth days of the treatment.
Results: There were not significant differences between placebo and vitamin A groups in the rate of normalization of clinical and laboratory findings.
Conclusion: These data show that supplementation of high doses of vitamin A has no additional advantage in the treatment of lower respiratory tract infections of infants.
Keywords: Lower respiratory tract infections, vitamin A
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