The publication of University of Health Sciences, Istanbul Sisli Hamidiye Etfal Medical Practice and Research Center

Online article submission system has been turned over to eJManager. We kindly request you to submit your current article or new articles via eJManager system

          VOLUME 36 / ISSUE 1

The Journal is Indexed in

4 - Use of intramuscular Midazolam, Meperidine and Morphine combined with Atropine in adult premedication

Müslüm Çiçek, Birsen Ekşioğlu, Ayda Başgül, Ayşe Hancı,Nebahat Sivrikaya

Objective: We aimed to compare the effects of midazolam, meperidine and morphine combined with atropine that used in adult premedication intramuscularly (im) on hemodynamics changes, sedation and anxiety.

Study Design: 200 patients with 17-74 years of age range from ASA I-II groups having elective operation were involved into study. Patients were divided into 4 equal groups with 50 persons, randomly. We determined the four groups as Group 1 (midazolam 0.07 mglkg+atropine 0.01 mg/kg), Group 2 (meperidine 1 mglkg+atropine 0. 01 mg/kg), Group 3 (morphine 0.01 mglkg+atropine 0.01 mg/kg) and group 4 (atropine 0.01 mg/kg). Drugs were given intramuscularly 45-60 minutes before operation. Sedation score, anxiety score, heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and adverse effects were recorded.

Results: Sedation and anxiety scores siginificantly decreased in all groups except for Group 4 (p<0.05). HR was increased significantly in these groups except for Group 3 (p<0.05). MAP in Group 3, RR in Group 1 and 3 were siginificantly decreased (p<0.05). In all groups, the most frequently seen adverse effect was the dry mouth.

Conclusions: We determined that im midazolam, meperidin and morphine were sufficient to abolish anxiety in adult premedication. We thought that the appropriate use of atropine should be whenever indication was present

Keywords: premedication, midazolam, meperidine, morphine, atropine.

To read full article click

Home Page       Editorial       Editorial Board       Advisory Board       Information for Authors       Contact       Archive

Copyright ® 2011 Sisli Etfal Hastanesi Tıp Bülteni