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11 - Malignant mesenchymal tumors of the uterus
Emine Yetkin, Cem Çomunoğlu, Deniz Özcan, Pınar Özay, Aylin Doğdu
Objective : Malignant mesenchymal tumors of the uterus are rare neoplasms. Uterine sarcomas comprises 3% of the whole uterine malignities. According to the architectural and cytopathological properties; these are malignant smooth muscle neoplasms (leiomyosarcomas), endometrial stromal sarcomas, malignant mixed müllerian tumors, undifferentiated uterine sarcomas and other malignant mesenchymal tumors. Leiomyosarcomas comprises 1 of 3 the whole uterine sarcomas. 10-15% of malignant mesenchmal tumors are endometrial stromal sarcomas. Malignant mixed müllerian tumors comprises less than 1,5% of the whole uterine malignities. This study evaluates retrospectively those patients diagnosed with malignant mesenchmal tumors of the uterus that came to our laboratory between 1996-2000.
Material and Method: In this report, 21 cases of uterine sarcomas, in evaluated Department of Pathology SSK Okmeydanı Hospital between 1996-2000, retrospectively evaluated with their histopathological properties. Cases were evaluated with paramétrés of the age, diametre of the tumor, degree of differentiation, mitosis, atypia, necrosis, cellularity, cell type, macroscopic properties of the cut surface, tumor borders, vascular invasion, endoservical invasion. Immunhistochemical study were applied for the chosen cases.
Results: Ten of these 21 cases were leiomyosarcomas (47%), 6 were malignant mixed müllerian, tumors (29%), 5 were endometrial stromal sarcomas(24%). With the aid of immunhistochemistry malignant mixed müllerian tumors are diagnosed more accurately, so incidence of them are getting increased. The incidence rate of our cases and the literature are concordant.
Keywords: Uterus, Leiomyosarcoma, endometrial stromal sarcoma, malignant mixed müllerian tumor.
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