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6 - Comparisons of oral calcium, high Dose vitamin D and combination of these in the treatment of nutritional in children
Günsel Kutluk, Feyzullah Çetinkaya, Muzaffer Başak, Merih Evküre, Metin Uysalol, Cengiz Asılsoy
Objective: Nutritional rickets still remains a common child health problem ind Turkey and many other developing countries. Although vitamin D deficiency is accepted as the basic problem underlying the disease, some others postulate that a deficiency of dietary calcium, rather than vitamin D, is often responsible for the nutritional rickets in sunny countries. We conducted a placebo-controlled study to determine the best treatment form in nutritional rickets in children from a lower socioecenomic group in İstanbul.
Study design: We enrolled 45 infants (aged 6-30 months) with rickets in a randomized, doble-blind, controlled trial of 4 weeks of treatment with vitamin D (300,000 U i.m.), calcium, phosphorus and alkaline phosphatase and used a 10-point radiographic score to assess the response to treatment.
Results : Treatment produced an increase in serum calcium and a decrease in alkaline phosphatase concentration in all three groups, but the most important increase was reached in vitamin D plus calcium group.
Conclusions: Vitamin D deficiency appears to be the primary etiologic factor of rickets in our children with rickets but a better response to treatment with vitamin D or in combination with calcium were taken than to treatment with vitamin calcium alone.
Keywords: Rickets, Vitamin D, Avitaminosis.
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