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          VOLUME 34 / ISSUE 4

The Journal is Indexed in

9 - Relationship Between Fasting Total Levels and Ischemic Heart Disease and Proteinuria in NIDDM Patients

Taner Baştürk,Yahya Öztürk,Sema Karul,Yüksel Altuntaş

OBJECTIVE: To assess the value of homocysteine as a potential candidate to explain the relationship between type II DM patients with elevated total homocysteine concentration with nephropathy and cardiovascular mortality and morbidity.

MATERIAL AND METHOD : 44 type II DM patients were included in the study. The patients were seperated into three groups and the homocysteine, creatinine, trygliceride, cholesterol, LDL, HDL, Hb A1C levels were compared between the groups.

RESULT: The homocysteine level differences between the groups were statistically significant (p<0.05); between group I and group II, homocysteine levels were higher in group II with proteinuric patients; between group I and group III, homocysteine levels were higher in patients with ischemic heart disease in group III; comparison between group II which had patients with ischemic heart disease and proteinuria had higher levels of homocysteine than group III. The other parameters did not show statistically significant differences between the groups (p>0.05).

CONCLUSION: Homocysteine levels were higher in the NIDDM patients with ischemic heart disease and/or proteinuria. It is concluded that doctors diagnosing and following up diabetic patients and trying to lower the risk of cardiovascular mortality and morbidity should take into consideration hyperhomocysteinemia, which is a treatable and independent risk factor.

Keywords: Homocysteine, NIDDM, 1HD, microalbuminurea

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