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5 - The immunglobulin Profile In Bacterial Infections
Mustafa Yıldız, Ayşen Kutan, Hülya Tanes Açıkel, Bülent Öztürk, Ebru Em, Sema Karul, Yüksel Altuntaş
Objective: Our study aimed to detect the quantitative profile of humoral defence in immune response developed against exracellular bacteria in various infections.
Study Design: In a group of 50 subject infected with exracellular bacteria, the quantitative evaluation of humoral immunity in practice, is carried out by detection of IgG, IgM, IgA parameters in plasma.
Results: 3 out of 19 subjects having respiratory system infection (%15,7) are found to have a significant deficit in IgG levels. The 3 out of the rest subjects having IgG deficit are also found to have IgA deficit. 8 out of 21 patients having genitourinary system infection (%38) are found to have an increase in IgA levels. 2 out of 21 subjects are also found to have a combined immunoglobulin increase (IgA- IgG, IgA- IgM).
Conclusion: In our study, the immunoglobulin profile of subjects with bacterial infection of respiratory and genitourinary system showed a significant deficit in IgG levels. We also found that there is a correlation between the decrease in IgG levels and the duration of the infection. In subjects having urinary system infection, in contrast to the results given in varies previous studies, we found a significant increase in IgA levels compared to subjects in control group.
Keywords: Bacterial infections, humoral immunity, IgG, IgA, IgM.
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