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2 - The Effect Of Oral And Parenteral Calcitriol On Secondary Hyperparathroidism In Chronic Haemodialysis Patients
Özlem Harmankaya, Taner Baştürk, Yahya Öztürk, Hakan Yapıcı
Object: This study was designed to compare the effects of oral and parenteral calcitriol on serum calcium, phosphorus, alkaline phosphatase and parathormone.
Material and Method: Twenty patients with end-stage renal failure on maintenance hemodialysis (10 males and 10 females, ages ranging between 22 and 80 years) were enrolled to the study. They were randomly assigned to two groups. The first group (n-11) was given active vitamin D (0.5-2 pgr) intravenously after every hemodialysis session, thrice per week. Second group (n=9) received oral calcitriol (0.25- 1.5 pgr/day). Serum calcium, phosphorus, alkaline phosphatase and parathormone levels were observed for six months.
Results: At the end of six months, the decrease in alkaline phosphatase levels in the IV calcitriol receiving group was statistically significant (p<0.05). The calcium and phosphorus levels in both groups and ALP levels in the oral calcitriol receiving group was not statistically significant (p>0.05). Parathormone levels were decreased in 37% of the IV calcitriol receiving group and 44% of the group on oral calcitriol therapy.
Conclusion: In patients on hemmodialysis theraphy, there was not a significant difference between the effects of oral or IV calcitriol on serum calcium, phosphorus, alkaline phosphatase and parathormone levels.
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