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          VOLUME 34 / ISSUE 3


The Journal is Indexed in


4 - The Effects of TIVA with Propofol - Fentanyl and Midazolam - Fentanyl Combinations On Haemodynamic Parameters and Recovery

Nevşin Bingöl Arda, G. Ulufer Sivrikaya, Dilek Tezal,Çağla Özbakış, Ayşe Hancı

OBJECTIVE: in our study, we aimed to compare the effects of propofol-fentanyl and midazolam-fentanyl combinations on haemodynamic parameters and recovery.

STUDY DESIGN: 40 patients undergoing gynaecological operation in ASA I-II, aged between 18-55 years randomized into two groups. Anaesthesia was induced with propofol 2-2.5 mg/kg in Group P, midazolam 0.3 mg/kg in Group M and fentanyl 3 microg/kg, atracurium 0.5 mglkg in both groups. Anaesthesia was maintained with propofol infusion in a rate of6-12 mg/kg/h in Group P and midazolam infusion in a rate of 0./ mg/kg/h in Group M. Peroperative haemodynamic parameters and postoperative recovery characteristics were evaluated.

RESULTS: A decrease in haemodynamic parameters was observed in both groups after induction, intubation, incision and peroperatively. Diastolic blood pressure values were more stable in Group M. Extubation time, time to responce to verbal stimulus,full orientation time and time to reach the total awareness according to Steward Scoring System were significantly shorter in Group P in recovery period.

CONCLUSION: Haemodynamic stability of propofol-fentanyl and midazolam-fentanyl combinations are found to be similar, while effects of propofol were superior than midazolam on recovery.

Keywords: Propofol, midazolam,fentanyl, haemodynamic parameters, recovery.

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