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4 - Relationship of blood lipid levels with Hba1c and obesity in patients with type 2 diabetes mellitus
Ebru Özdoğan, Osman Özdoğan, Esma Güldal Altunoğlu, Ali Rıza Köksal
Objective: Dyslipidemia play an important role in the development of coronary artery disease (CAD) which is the worlds leading cause of mortality. Diabetes mellitus and obesity can cause CAD by different ways; dyslipidemia is common in both of them, that can lead to CAD. We investigate the effect of obesity and poor glycemic control on lipid profile in diabetic patients, in our country.
Material and Method: One hundred and sixty five patients (82 male) who admitted to Istanbul Education and Research Hospital Outpatient Diabetes department, whose known diabetes age was less than 5 years, not taking any anti-lipidemic medicine in the last 6 months, not having ischemic heart disease, diabetes controlled by only oral antidiabetics, non-smoker and not drinking alcohol, dont having any endocrine disorder with possible affect on blood lipid levels, were enrolled to the study. The relationship between lipid levels and HbA1c, body mass index (BMI) and diabetes age were assessed. Students t test, ANOVA and Pearson correlation tests were used for comparisons. p<0.05 was considered significant.
Results: It was determined that when BMI value increased, cholesterol, triglyceride and LDL levels increased (r=0.46 p<0.001, r=0.58 p<0.001, r=0.34 p<0.01, respectively) and HDL levels decreased (r=-0.37 p<0.001 ). In patients having high HbA1c levels, total cholesterol, triglyceride and LDL cholesterol levels were found high (r=0.27 p<0.001, r=0.29 p<0.001, r=0.20 p<0.05, respectively). A positive correlation was found between the increasing diabetes age and HbA1c levels (r=0.28, p <0.001) was determined, but no significant corelation with blood lipid levels was detected.
Conclusion: We found similar but not identical results with previous international studies, in this study done in our country. Lipid profile was adversely effected in diabetic patients having obesity and poor glycemic control.
Keywords: Type 2 diabetes, BMI, HbA1c, lipid profile
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