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2 - The effect of estradiol and prolactine levels on embryo quality and pregnancy outcomes on the day of human chorionic gonadotrophine of patients who have down regulation with GnRH agonist and antagonist in ICSI/ET cycles
Osman Temizkan, Ebru Çögendez, İlhan Şanverdi, Şule Temizkan, Tayfun Kutlu, Işıl Ayhan, Bülent Arıcı, Osman Aşıcıoğlu
Objective: In patients who have normal ovarian response in vitro fertilization (IVF) during GnRH-agonist and GnRH-antagonist treatment on embryo quality and E2 and prolactine levels on human chorionic gonadotropine day; pregnancy outcomes were evaluated.
Gereç ve Yöntemler: Analyse of 115 women aged 1840 years who underwen to varian hyperstimulation in fresh cycles down regulated either with GnRH agonist (n=44) or GnRH antagonist (n=71) followed by oocyte pick-up, intracytoplasmic sperm injection (ICSI) and embryo transfer are prospectively analyzed. PRL and E2 values performed basal and on the day of hCG injection. Demographic data, ovarian responses, endometrial thickness, development of embryo and IVF result among groups were compared.
Results: Treatment protocols of the number of oocyte sobtained as a result, the number of oocytes and thenumber of mature oocytes that fertilized and not statistically different. Endometrial thickness and endometrial appearance day of hCG, which is viewed as ultrasound, serum E2 (1818±1064 pg/mL vs 1592±860 pg/ml, respectively, p>0.05) and PRL (34.2±20.1 ng/mL vs 30.3±15.4 ng/ml, respectively, p>0.05) were not statistically different between the two groups. GnRH-agonist and GnRH-antagonist result of treatment cycles with fertilization rate (60.3% and 60.9%, respectively, p>0.05), implantation rate (20.5% and 23.5%, respectively, p>0.05), pregnancy rate (27.3% and 21.1%, respectively, p>0.05) was not statistically different. Pregnancy rates for the day of hCG viewed E2 and PRL for AUC levels ROC curve analysis results of IVF / ICSI was observed cycles can not be used to predict the occurrence of pregnancy (AUC 0.505, 95% CI: 0372-0638; AUC 0.412, 95% CI: 0.286 to 0.537, respectively).
Conclusions: GnRH-agonist or GnRH-antagonist protocol in patients with normal ovarian response had no effect on embryo quality and diversity of this treatment has been shown to affect pregnancy outcomes. GnRH agonists and antagonists on day of hCG in cycles E2 and PRL mean blood levels viewed were not significantly different. Inaddition, the day of hCG viewed E2 and PRL showed no significant use in predicting the occurrence of pregnancy.
Keywords: Embrio quality, pregnangy outcome, Estradiol on hCG day, Prolactine on hCG day, GnRH agonist treatment, GnRH antagonist treatment
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