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5 - Non-HDL cholesterol, total cholesterol/HDL cholesterol and LDL-cholesterol levels in patients with acute ischemic stroke
Nihal Boğdaycıoğlu, Müjgan Ercan, Sema Uysal, Semra Mungan Öztürk, Fatma Meriç Yılmaz
Objective: Ischemic stroke is defined as acute neurological disorder according to cerebral vascular damage and reduced blood flow to a particular region of the brain. Ischemic stroke is a major cause of morbidity and mortality and placed 3rd among the causes of death. About 80% of all strokes depend on ischemic cause. Atherosclerotic plaque rupture or addition of a thrombus on plaque is the most common cause of ischemic stroke. Atherosclerosis is associated with the level of blood lipids from the first stages of the formation process. In our study, we aimed to investigate non-HDL, total cholesterol / HDL-cholesterol and LDL-cholesterol levels in patients with acute ischemic stroke.
Methods: This study was performed in 52 patients who were admitted at Ankara Numune Hospital for Education and Investigation, Division of Neurology between December 2009- May 2010 with a diagnosis of acute ischemic stroke in the first 24 hours and 48 healthy individuals matched for age and gender, who was admitted at the hospital during the same period. Total cholesterol, triglycerides and HDL cholesterol levels were measured by DXC 800 autoanalyzer (Beckmann-Coulter, USA). LDL cholesterol, total cholesterol / HDL-cholesterol and non-HDL cholesterol levels were calculated according to the formulas.
Results: Patient group had significantly lower HDL-C levels than the control group (p=0.009), whereas the triglyceride and total cholesterol / HDL-C levels were significantly higher (p=0.013, p=0.018). Total cholesterol, LDL cholesterol and non-HDL cholesterol levels did not differ significantly between groups. There were significant correlations between non-HDL-cholesterol levels and triglycerides, total cholesterol, LDL cholesterol (respectively r=0.468, r=0.964, r=0.851) (respectively p<0.001, p<0.001, p<0.001), and there was not a statistically significant correlation between non HDL -cholesterol and HDL cholesterol.
Conclusion: Dyslipidemia process plays a role in the pathogenesis of atherosclerosis which is an important risk factor for acute ischemic stroke. In our study, in terms of total cholesterol, non-HDL cholesterol and LDL cholesterol levels, there was not a significant difference but triglyceride, total cholesterol / HDL-cholesterol and HDL cholesterol levels were found to be significantly different.
Keywords: Acute ischemic stroke, LDL-cholesterol, non-HDL cholesterol
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