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          VOLUME 42 / ISSUE 3

The Journal is Indexed in

2 - The effects of different doses of intranasal midazolam used for premedication in children


Objective: Midazolam is a benzodiazepine and frequently preferred as a premedicant agent. Nasal application of the drugs has important advantages as; rapid absorbtion and rapid onset caused by rapid absorbtion of the drug to the systemic circulation. In our study; we aimed to compare the effects of different doses of intranasal midazolam on sedation and parental seperation when used for premedication in pre-scholl children. Study design: After the approval of Ethics Committee of Sisli Etfal Training and Research Hospital and informed consent of the parents, 60 patients aged 2-6 years in ASA I-II physical status randomized into three groups. Premedication was produced with intranasal midazolam with 0.3 mg/kg in Group I, 0.4 mg/kg in Group II and 0.5 mg/kg in Group III. Sedation and parental seperation scores and adverse effects were recorded as study parameters. Results: Sedation scores were similar between the three groups (p>0.05). Sedation scores were significantly lower in 25. and 30. minutes compared to 10. min in all three groups (p<0.05). Parental seperation scores were similar between the groups (p>0.05). Conclusion: We conclude that; 0.3 mg/kg intranasal midazolam is an effective and safe dosage when conscious sedation was aimed for premedication in pre-school children and higher doses are not necessary.

Keywords: Premedication, midazolam, intranasal

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