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1 - Importance of serum and urine tripsinogen activation peptid in acute pancreatitis
Yasin Kara, Tamer Karsidag, Sefa Tüzün
Objective: In this study, the biochemical markers which can be used to detect early stage, and prognosis of the severity of pancreatitis were studied.
Methods: According to clinical and laboratory findings, 38 patients with the diagnosis of acute pancreatitis were included in the study group. On admission, 24 and 48 hours later, blood and urine samples of patients were taken, and clinical evaluations were performed. Amylase, creatine phospho kinase, blood leukocytes, serum Trypsinojen activation peptide, activation peptide values Trypsinojen urine, the Apache-II illness severity score and Ranson criterias for pancreatitic mortality was recorded three times for each patients.
Results: Between Apache-II score on admission and leukocytes and serum TAP values on admission, as well as 48th hour Apache-II score showed a significant correlation between 48th hour CRP and serum TAP values. 48th hour blood leukocytes showed a significant correlation between 48th hour Apache-II score, C-reactive protein (CRP) and serum TAP values. There was no meaningful correlation between urine TAP values and leukocyte values on admission and at 48th hour. Arrival, 24th hour and 48th hour serum and urine TAP of patients were compared with the control groups and we found significant differences for all three time periods.
Conclusion: Serum and urine TAP in acute pancreatitis has increased by approximately three fold when compared with healthy individuals. These values were high on admission.
Keywords: Acute pancreatitis, tripsinogen activation peptid, tripsinogen-2
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