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1 - The independent prognosting value of HbA1c leves effects on early mortality in patients with acute coronary syndrome (ACS)
Güzin Zeren Öztürk, Öykü Aksoy, Osman Kara, Tülin Kurt, M. Ali Çıkrıkçıoğlu, Mustafa Çakırca, Tufan Tükek
Aim: HbA1c is a mark shows chronic glucose dysregulation. We investigated the independent prognosting value of HbA1c leves in predicting early mortality in patients with acute coronary syndrome (ACS).
Method:This was a single center,retrospective study carried up at Vakif Gureba Training and Research Hospital. Five hundred patients who admitted to coronary intensive unit(CIU); because of ACSwere evaluated. We excluded patients who have chronic diesease which may affect the mortality (such as chronic heart failure, chronic renal failure, arrhythmia, Diabetes Mellitus, and cirrhosis). Their first CIU labratory measurements were analyzed and compared . Their first month polyclinic control documents searched to learn their health status. When we determined that the patient did not come to control we contacted his/her home number and taked information about patients health.
Results: In this retrospective study, 500 patients who admitted to coronary intensive unit(CIU) because of ACS were evaluated. The highest HbA 1c value was 12,58% and the lowest finded value was 4,18% (avarage was 6,71%). The patient who didnt come to one month polyclinic control after ACS ; phoned from homephone to learn about his/her health. Twenty three of them died (13 were male and 10 were female). When died and alive patients compared ;the 1st admission blood glucose and BUN levels of patients that died were higher than those not died after 1 month of follow-up (189±119 versus 135±80mg/dL, p=0,041 and 68,91±30,72 versus 43,79±24,75 mg/dl, p< 0,001, respectively). But there was no significant difference in HbA1c levels between these two groups (6,6±1,6 versus 6,71±2,07%, p= 0,917).
Conclucion: In our study on acute coronary syndrome, admission blood glucose,BUN, creatinin, and HbA1c values were compared in patients that died and still alive after 1 month of CIU admission. There was no correlation between admission HbA1c values and early mortality in these patients. On the other hand, admission blood glucose and BUN values were correlated with early mortality of these patients.
Keywords: HbA1c acute coronary syndrome (ACS) early mortality effect
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