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3 - Comparison of ABO and Rh group incompatibility for neonatal indirect hyperbilirubinemia
Fatih Bolat, Sinan Uslu, Ali Bülbül, Serdar Cömert, Ömer Güran, Evrim Kiray Baş, Asiye Nuhoğlu
Aim: to evaluate clinical and labaratory findings between ABO and Rh incompatability and to compare the results of groups in terms of severe hyperbilirubinemia.
Methods: Term neonates with indirect hyperbilirubinemia due to ABO and Rh blood group incompatibilities who were hospitalized in Neonatal Intensive Care Unit between 2008 and 2010 were included and evaluated retrospectively. Among the two groups, Serum total bilirubin levels, hematocrit levels, direct coombs test results, existance of severe hyperbilirubinemia levels, phototherapy duration, IVIG usage and rates of exchange transfusion were compared.
Results: During the period, 1610 newborns were admitted to Neonatal Intensive Care Unit for two years. Of the patients, 420 (%26) were diagnosed as indirect hyperbilirubinemia. ABO and Rh incompatability were found in 123 (%29,2) and 27 (%6,4), respectively. There was similar to demographic characteristics. Severe hyperbilirubinemia was seen more often in ABO incompatibility group (p=0,04). Serum total bilirubin levels at 2nd (p=0,01) and 3rd days (p=0,001) were found to be higher in ABO incompatibility group. IVIG was used more often in Rh incompatibility group(p=0,009). Five patients; 4 of them with ABO group incompatibility and 1 with Rh group incompatibility had undergone exchange transfusion. None of the patients were diagnosed of hearing loss.
Conclusion: ABO incompatibility is an important cause of indirect hyperbilirubinemia. Close follow-up of patient with ABO incompatability in antenatal and postnatal period could decrease morbidity due to ABO incompatability.
Keywords: Newborn, ABO and Rh group incompatibility, indirect hyperbilirubinemia
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